Annals of Medicine and Surgery · 9 authors, 8 centres
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This correspondence summarizes mechanistic and clinical literature suggesting vitamin D's potential role as an immunomodulator against COVID-19. The authors argue that vitamin D's effects on immune regulation and the renin-angiotensin system could help manage the disease.
This correspondence letter reviews the proposed mechanisms by which vitamin D may influence COVID-19 pathogenesis and severity. The authors describe vitamin D as an immunomodulator that can upregulate antimicrobial peptides like cathelicidin, promote anti-inflammatory effects, and modulate the renin-angiotensin system. They state that a positive correlation between COVID-19 and vitamin D deficiency is reported by many workers and reference randomized trials and meta-analyses showing protective effects of supplementation. The authors suggest vitamin D may be useful in routine management, particularly for severe COVID-19. Its implications are speculative, proposing vitamin D's potential utility based on described biological plausibility and cited prior studies.
