SEARCHNARRATIVE_REVIEWimmunology, preclinical research

narrative_review·immunology, preclinical research, vitamins, micronutrients, infectious disease·PMC10528041

Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens

Cells · 11 authors, 6 centres

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TL;DR

This narrative review compiles literature on how vitamin D modulates mast cell activity through the vitamin D receptor, stabilizing mast cells to suppress pro-inflammatory mediators while also enhancing antimicrobial peptide production for pathogen defense.

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201 CHARS

This narrative review synthesizes literature on the immunomodulatory effects of vitamin D on mast cells, covering vitamin D receptor signaling, mast cell stabilization, and pathogen defense mechanisms.

STUDY TYPE

narrative_review

SPECIALTY

immunology

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100% · A

ORIGINAL PAPER

PMC10528041

Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens

Cells

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ABSTRACT

Abstract Mast cells (MCs) are abundant at sites exposed to the external environment and pathogens. Local activation of these cells, either directly via pathogen recognition or indirectly via interaction with other activated immune cells and results in the release of pre-stored mediators in MC granules. The release of these pre-stored mediators helps to enhance pathogen clearance. While MCs are well known for their protective role against parasites, there is also significant evidence in the literature demonstrating their ability to respond to viral, bacterial, and fungal infections. Vitamin D is a fat-soluble vitamin and hormone that plays a vital role in regulating calcium and phosphorus metabolism to maintain skeletal homeostasis. Emerging evidence suggests that vitamin D also has immunomodulatory properties on both the innate and adaptive immune systems, making it a critical regulator of immune homeostasis. Vitamin D binds to its receptor, called the vitamin D receptor (VDR), which is present in almost all immune system cells. The literature suggests that a vitamin D deficiency can activate MCs, and vitamin D is necessary for MC stabilization. This manuscript explores the potential of vitamin D to regulate MC activity and combat pathogens, with a focus on its ability to fight viruses. Keywords: vitamin D, MC, vitamin D receptor, viral infection

CITATION EXPORT

Yeganeh Mehrani, Solmaz Morovati, Sophie Tieu et al.. Vitamin D Influences the Activity of Mast Cells in Allergic Manifestations and Potentiates Their Effector Functions against Pathogens. Cells. (2023). https://doi.org/10.3390/cells12182271

AUTHORS

11 · 6 CENTRES

Yeganeh Mehrani, Solmaz Morovati, Sophie Tieu, Negar Karimi, Helia Javadi, Sierra Vanderkamp, Soroush Sarmadi, Tahmineh Tajik, Julia E Kakish, Byram W Bridle, Khalil Karimi

1Department of Pathobiology, Ontario Veterinary College, University of Guelph, Guelph, ON N1G 2W1, Canada; [email protected] (Y.M.); [email protected] (S.T.); [email protected] (S.V.); [email protected] (J.E.K.)
2Department of Clinical Sciences, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad 91779-48974, Iran; [email protected]
3Division of Biotechnology, Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz 71557-13876, Iran; [email protected]
4Department of Medical Sciences, Schulich School of Medicine & Dentistry, University of Western Ontario, London, ON N6A 3K7, Canada; [email protected]
5Department of Microbiology and Immunology, Faculty of Veterinary Medicine, University of Tehran, Tehran 14174-66191, Iran; [email protected]
6Department of Pathobiology, School of Veterinary Medicine, Ferdowsi University of Mashhad, Mashhad 91779-48974, Iran; [email protected]