SEARCHCOHORToncology, nutrition

cohort·oncology, nutrition, epidemiology, public health, micronutrients·PMC10483107

Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study

Journal of Epidemiology · 5 authors, 8 centres

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TL;DR

In a prospective cohort of 42,166 Japanese adults followed for a median of 14.6 years, higher dietary vitamin K intake was inversely associated with incident lung cancer, with the highest versus lowest quartile multivariable HR of 0.67.

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This prospective cohort study used a validated food frequency questionnaire to assess baseline dietary vitamin K intake in 42,166 Japanese adults and followed them for a median of 14.6 years (564,127 person-years), documenting 430 incident lung cancer cases.

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cohort

SPECIALTY

oncology

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100% · A

ORIGINAL PAPER

PMC10483107

Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study

Journal of Epidemiology

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ABSTRACT

Background Limited reports from prospective human studies investigated the possible role of vitamin K in the development of lung cancer although vitamin K’s anticarcinogenic activities were verified from several in vitro and in vivo studies. We investigated the associations between total vitamin K intake from food and the development of lung cancer based on this large prospective cohort study. Methods A validated food frequency questionnaire was used to examine vitamin K intake among 42,166 (16,341 men and 25,825 women) at the Japan Collaborative Cohort Study’s baseline (1988–1990). Hazard ratios (HRs) and 95% confidence intervals (CIs) of incident lung cancer were calculated using the Cox proportional hazard regression method based on vitamin K consumption quartiles. Results 430 cases (308 males and 122 women) of lung cancer were documented during a total of 564,127 person-years of follow-up (median follow-up, 14.6 years). Vitamin K consumption was shown to be inversely related to lung cancer risk; the multivariable hazard ratio [HR] for the highest versus lowest quartiles was 0.67 (95% confidence interval [CI], 0.46–0.96; P for trend = 0.010). This relationship appears to be stronger in males (HR 0.62; 95% CI, 0.40–0.96; P for trend = 0.016) than in females (HR 0.82; 95% CI, 0.42–1.61; P for trend = 0.39) ( P for interaction = 0.012), and in ever smokers (HR 0.57; 95% CI, 0.36–0.91; P for trend = 0.006) than in never smokers (HR 0.79; 95% CI, 0.40–1.55; P for trend = 0.37) ( P for interaction = 0.30). The individuals’ age, body mass index, or alcohol consumption status had no effect on the observed connection. Conclusion Vitamin K consumption reduces the risk of lung cancer. More research is needed to clarify the molecular processes behind this connection.

CITATION EXPORT

Fangyu Yan, Ehab S. Eshak, Ahmed Arafa et al.. Vitamin K Intake and Risk of Lung Cancer: The Japan Collaborative Cohort Study. Journal of Epidemiology. (2023). https://doi.org/10.2188/jea.JE20220063

AUTHORS

5 · 8 CENTRES

Fangyu Yan, Ehab S. Eshak, Ahmed Arafa, Akiko Tamakoshi, Hiroyasu Iso

1Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine, Osaka, Japan
2Center for Surveillance, Immunization, and Epidemiologic Research, National Institute of Infectious Diseases, Tokyo, Japan
3Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University, Minia, Egypt
4Advanced Clinical Epidemiology, Medical Data Science, Osaka University Graduate School of Medicine, Osaka, Japan
5Public Health, School of Health, Calvin University, Michigan, USA
6Department of Public Health, Faculty of Medicine, Beni-Suef University, Beni-Suef, Egypt
7Department of Public Health, Graduate School of Medicine, Hokkaido University, Sapporo, Japan
8Institute for Global Health Policy Research, Bureau of International Health Cooperation, National Center for Global Health and Medicine, Tokyo, Japan