Antioxidants · 7 authors, 8 centres
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This PRISMA-compliant systematic review of 38 ex vivo, in vitro, and in vivo studies found that only vitamins A, C, D, and E demonstrate radioprotective properties, with vitamin E showing the strongest evidence followed by vitamins C, A, and D.
This systematic review followed PRISMA guidelines, searching PubMed and Embase for English-language studies published from January 2001 to January 2023, yielding 38 included articles: 27 in vivo, 9 in vitro, and 2 ex vivo. The review assessed the radioprotective effects of vitamins used alone, in combination, or with other nutritional and non-nutritional compounds. Vitamins A, C, D, and E were identified as having radioprotective properties, with vitamin E ranked highest, followed by C, A, and D. Among vitamin E isoforms, tocotrienols showed higher radioprotective effect than tocopherols, though low bioavailability limits clinical application. Vitamin D demonstrated anti-inflammatory, antioxidant, and radioprotective effects on lacrimal glands in an in vivo model.
