Investigative Ophthalmology & Visual Science · 8 authors, 5 centres
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This cohort study used untargeted metabolomics on vitreous humor from 31 intermediate AMD patients and 30 controls undergoing vitrectomy. Fatty amides and acyl carnitines were increased while succinic acid and nicotinamide were decreased in the AMD group, suggesting altered lipid and energy metabolism may be implicated in AMD pathogenesis.
Untargeted metabolomics was performed using high-resolution liquid chromatography mass spectrometry on vitreous humor collected during vitrectomy from 31 patients with intermediate AMD and 30 controls. Of 858 metabolites analyzed, 258 distinguished AMD patients from controls (P < 0.05). Fatty amides (e.g., docosanamide, anandamide) and acyl carnitines (e.g., acetyl L-carnitine, L-palmitoylcarnitine) were elevated, while succinic acid (−1.69-fold) and nicotinamide (−0.55-fold) were reduced in AMD vitreous. Ascorbic acid (14.09-fold) and uric acid were also increased. Pathway analysis showed enrichment in oxidation of branched-chain fatty acids and carnitine synthesis. Limitations include the cross-sectional design, inability to establish causality, potential confounding from AREDS2 supplement use, and lack of concurrent fasting plasma samples.
