São Paulo Medical Journal · 7 authors, 5 centres
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This umbrella review of 27 Cochrane systematic reviews found moderate- to high-quality evidence of benefit from vitamin D supplementation for pregnant women and asthma patients, no benefit for fracture prevention when vitamin D is used alone, and low or uncertain evidence for all other clinical conditions assessed.
This umbrella review identified and qualitatively synthesized 27 Cochrane systematic reviews (10 on prevention, 17 on treatment) evaluating vitamin D supplementation across various clinical conditions. No benefit was found for vitamin D alone (without calcium) for preventing hip or any new fracture. The authors noted that most included trials had methodological limitations including small sample sizes, insufficient follow-up, and unclear randomization or blinding methods, limiting the quality of evidence for most outcomes. Eight reviews could not provide reliable evidence regarding benefits or harm.
