BMC Complementary Medicine and Therapies · 2 authors, 1 centre
This summary was generated by AI from a single paper. It has not been reviewed by a clinician and is not clinical advice. Verify against the source before acting on it.
This preclinical study in rats found that oral administration of Nigella sativa oil before cranial gamma irradiation preserved the histological structure of parotid glands and reduced fibrosis and TGF-β expression compared to irradiation alone.
Twenty-eight male albino rats were divided into four groups (n=7) to investigate the radio-protective effect of Nigella sativa oil (NSO, 400 mg/kg) on parotid glands exposed to 15 Gy cranial gamma irradiation. Histological and immunohistochemical analyses were performed two weeks after treatment. Gamma irradiation alone caused loss of acinar architecture, fibrosis, and high TGF-β expression. Treatment with NSO before irradiation preserved acinar outline, reduced fibrosis, and led to moderate TGF-β expression.
