Women of reproductive age living in the North of the Netherlands: Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort

BMJ Open · 5 authors, 5 centres

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TL;DR

This paper describes the creation and baseline characteristics of a population-based cohort of 5412 women of reproductive age. It provides epidemiological data on reproductive health, including prevalence of infertility consultations, treatment types, pregnancy outcomes, and postpartum health.

Full summary

951 CHARS

The study establishes the Lifelines-ROAHD cohort, embedding 5412 women from the population-based Lifelines cohort. Central results include that 45.6% of women had a natural menstrual cycle, 16.8% consulted for infertility, and among them, anovulation (24.4%), male partner infertility (22.5%), or unexplained infertility (22.2%) were diagnosed. Treatments included ovulation induction (19.8%) and IVF (5.4%). There were 6158 pregnancies and 5068 births, with adverse outcomes such as miscarriage (14.3%) and ectopic pregnancy (0.9%). Delivery modes were primarily vaginal (74.9%). A strength is the rich, detailed dataset and linkage to prior Lifelines data. Limitations include potential recall bias from retrospective collection and a 19.3% response rate among eligible Lifelines participants, though demographic comparisons suggest generalizability. The cohort enables future longitudinal research on how reproductive events influence later health.

STUDY TYPE

cohort

SPECIALTY

epidemiology

SUMMARISED BY

AI pipeline

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ORIGINAL PAPER

PMC10186082

Women of reproductive age living in the North of the Netherlands: Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort

BMJ Open

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ABSTRACT

Abstract Purpose The Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort provides a uniquely detailed dataset allowing investigations of determinants of reproductive health as well as the influence of reproductive events on future health and disease of mother and child(ren). Lifelines-ROAHD cohort is embedded in the population-based Lifelines cohort study. Participants In total, 5412 women of reproductive age (20–45 years) were included in the Lifelines-ROAHD cohort, in the period 2017–2018. Findings to date In the population, 45.6% of the women indicated that they had a natural menstrual cycle. In total, 908 women (16.8%) consulted a healthcare provider for infertility; subsequently diagnosed fertility problems were anovulation (24.4%), male partner infertility problems (22.5%) or unexplained infertility (22.2%). Women underwent various consecutive assisted reproductive treatments, for example, ovulation induction (19.8%) or in vitro fertilisation (5.4%). In total, 2808 women experienced 6158 pregnancies and 5068 births. Adverse pregnancy outcomes were miscarriage (14.3%), ectopic pregnancy (0.9%) or termination of pregnancy or medical abortion (2.0 %). The modes of delivery were vaginal births (74.9%), instrumental vaginal births (11.9%), elective caesarean section (3.9%) and emergency caesarean section (9.3%). Birth outcomes were born alive at term (93.6%), born alive (very) pre-term (5.8%), stillbirth (0.316%) and neonatal death (0.197%). Additional data about 2660 most recent pregnancies showed that 19.9% of the women had irregular working hours. One year postpartum, women indicated adverse physical health issues in one or more domains, range 0.5%–12.5%. They also indicated adverse psychological health issues in one or more domains, range 0.7%–1.6%, and 1.6% experienced diminished sexual health. Future plans Due to the embedding of Lifelines-ROAHD cohort in the original Lifelines cohort, the women will be longitudinally followed. Additionally, we aim to collect data with a second online questionnaire aiming to complete women’s reproductive histories, by collecting data about potential first and subsequent pregnancies conceived after the date of completion of baseline Lifelines-ROAHD cohort. Keywords: reproductive medicine, epidemiology, subfertility, obstetrics

CITATION EXPORT

Lilian L Peters, Henk Groen, Anna Sijtsma et al.. Women of reproductive age living in the North of the Netherlands: Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort. BMJ Open. (2023). https://doi.org/10.1136/bmjopen-2022-063890

AUTHORS

5 · 5 CENTRES

Lilian L Peters, Henk Groen, Anna Sijtsma, Danielle Jansen, Annemieke Hoek

1Department of Primay and Long-Term Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
2Department of Midwifery Science/Midwifery Academy Amsterdam Groningen, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
3Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
4Lifelines Cohort Study, University Medical Centre Groningen, Groningen, The Netherlands
5Department of Obstetrics and Gynaecology, Section Reproductive Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands